5,7-Dichlorobenzofuran → (RS)-2-[1-(5,7-Dichloro-benzofuran-2-yl)-methanoyl]-4-methyl-piperazine-1-carboxylic acid tert-butyl ester

HRID 2077307Notes

Reaction equation

HRID 2077307 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH:9]1[C:15](=[O:20])N(OC)C)=[O:7])([CH3:4])[CH3:3].[Cl:21][C:22]1[CH:23]=[C:24]([Cl:31])[C:25]2[O:29][CH:28]=[CH:27][C:26]=2[CH:30]=1>>[C:2]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH:9]1[C:15]([C:28]1[O:29][C:25]2[C:24]([Cl:31])=[CH:23][C:22]([Cl:21])=[CH:30][C:26]=2[CH:27]=1)=[O:20])=[O:7])([CH3:1])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 900145,7-DichlorobenzofuranHCID 86625772(RS)-2-(methoxy-methyl-carbamoyl)4-methyl-piperazine-1-carboxylic acid dimethyl-ethyl ester

Product 1

HCID 66968136(RS)-2-[1-(5,7-Dichloro-benzofuran-2-yl)-methanoyl]-4-methyl-piperazine-1-carboxylic acid tert-butyl ester

Procedure

The title compound (0.94 g) was prepared from (RS)-2-(methoxy-methyl-carbamoyl)-4-methyl-piperazine-1-carboxylic acid dimethyl-ethyl ester, D54 (1.00 g) and 5,7-dichloro-benzofuran (0.65 g, FP1.537.206) using the method of Description 2.

Sources & evidence

ORD record
ord-7f180e0e62564534bd22ad48bdb13578
Source dataset
uspto-grants-2011_04
Patent number
US07928124B2

Reaction notes

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