Dichloromethane → 1-(2-Hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid

HRID 207734Notes

Reaction equation

HRID 207734 reaction equation
[Cl:47][CH2:48][Cl:49].[F:40][C:41]([F:42])([F:43])[C:44]([OH:45])=[O:46].[OH:1][CH:2]([CH2:3][N:4]1[CH2:5][CH:6]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:7]1)[c:15]1[cH:16][cH:17][c:18](-[c:21]2[n:22][o:23][c:24](-[c:26]3[n:27][o:28][c:29](-[c:34]4[cH:35][cH:36][cH:37][cH:38][cH:39]4)[c:30]3[CH2:31][CH2:32][CH3:33])[n:25]2)[cH:19][cH:20]1>>[OH:1][CH:2]([CH2:3][N:4]1[CH2:5][CH:6]([C:8](=[O:9])[OH:10])[CH2:7]1)[c:15]1[cH:16][cH:17][c:18](-[c:21]2[n:22][o:23][c:24](-[c:26]3[n:27][o:28][c:29](-[c:34]4[cH:35][cH:36][cH:37][cH:38][cH:39]4)[c:30]3[CH2:31][CH2:32][CH3:33])[n:25]2)[cH:19][cH:20]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58374129tert-Butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate

Product 1

HCID 509232721-(2-Hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid

Sources & evidence

ORD record
ord-9ee047ba85ba49ada1dcde20b58540f7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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