HCID 59715735, compound → HCID 59715643, compound

HRID 2078012Notes

Reaction equation

HRID 2078012 reaction equation
[CH2:1]([C:5]1[CH:23]=[CH:22][C:8]([CH2:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:20]#[CH:21])[CH:18]=3)[CH:13]=[CH:12][N:11]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]>O1CCCC1.[C].[Pd]>[CH2:1]([C:5]1[CH:23]=[CH:22][C:8]([CH2:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([CH2:20][CH3:21])[CH:18]=3)[CH:13]=[CH:12][N:11]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 59715735HCID 59715735, compound

Product 1

HCID 59715643HCID 59715643, compoundYield 10.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Palladium-carbon (10%, 5.0 mg) was added to a solution of the compound of Example B158 (2.0 mg) in tetrahydrofuran (2.0 ml), and the mixture was stirred at room temperature under nitrogen atmosphere (1 atm) for 1 hour. The catalyst was removed by filtration, and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give the title compound (0.21 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-bec22970982e4087b4c66774447f98eb
Source dataset
uspto-grants-2011_04
Patent number
US07928209B2

Reaction notes

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