反应详情

A mixture of 1,1-dimethylethyl N-((4-hydroxy-5-(methyloxy)-2-oxo-2′,3′,5′,6′-tetrahydro-spiro[naphthalene-1,4′-pyran]-3-yl)carbonyl)glycinate (32 mg, 77 μmol) in 2 mL TFA was stirred at room temperature for 30 minutes, M+1=362, M−1=360. The mixture was concentrated in vacuo, and purified by column chromatography eluting with 0.1:10:100 TFA/MeOH/DCM to give 9 mg of the product as a pale yellow solid. MS (m/z)=362 (M+H)+. Calculated for C18H19NO7 361.12.

1. concentrationThe mixture was concentrated in vacuo
2. custompurified by column chromatography
3. washeluting with 0.1:10:100 TFA/MeOH/DCM