HRID2078102

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)CNC(=O)C1=C(O)c2c(C(F)(F)F)cccc2C(C)(C)C1=O

HCID67099716

未命名化合物

PRODUCTS

生成物

结构：CC1(C)C(=O)C(C(=O)NCC(=O)O)=C(O)c2c(C(F)(F)F)cccc21

HCID57983468

未命名化合物

收率 6.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

1,1-Dimethylethyl N-((4-hydroxy-1,1-dimethyl-2-oxo-5-(trifluoromethyl)-naphthalen-3-yl)carbonyl)glycinate (30 mg, 73 μmol) was stirred in TFA (5 mL) for 15 minutes. The TFA was then removed under vacuum. The residue was purified by preparatory scale TLC (5% MeOH/DCM eluent) to give the desired product as a light yellow oil (1.6 mg). MS (m/z)=358.4 (M+H)+. Calculated for C16H14F3NO5 357.08.

WORKUP

后处理

customThe TFA was then removed under vacuum
customThe residue was purified by preparatory scale TLC (5% MeOH/DCM eluent)