HCID 178451289, compound → HCID 178429096, compound

HRID 2078335Notes

Reaction equation

HRID 2078335 reaction equation
[OH:1][C:2]1[C:3]([CH3:33])([CH3:32])[C:4]2[C:9]([C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])=[O:13])=[CH:8][CH:7]=[C:6](/[CH:24]=[CH:25]/[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH:5]=2>C(O)(C(F)(F)F)=O>[OH:1][C:2]1[C:3]([CH3:33])([CH3:32])[C:4]2[C:9]([C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])=[CH:8][CH:7]=[C:6](/[CH:24]=[CH:25]/[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[CH:5]=2

Participants

3

Reactant 1

HCID 178451289HCID 178451289, compound

Product 1

HCID 178429096HCID 178429096, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

(E)-tert-butyl 2-(2-hydroxy-1,1-dimethyl-4-oxo-7-styryl-1,4-dihydronaphthalene-3-carboxamido)acetate (120 mg, 268 μmol) was dissolved in TFA (2 mL) and stirred at room temperature for 30 minutes. The reaction mixture was concentrated, suspended in hexanes, filtered, washed with hexanes, and dried in a vacuum oven to give the title compound. MS (ESI) m/z: Calculated; 391.4: Observed; 392.0.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. filtrationfiltered
  3. washwashed with hexanes
  4. customdried in a vacuum oven

Sources & evidence

ORD record
ord-7704a80a70a445fe97d63acccf489f90
Source dataset
uspto-grants-2011_04
Patent number
US07928139B2

Reaction notes

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