HCID 178451292, compound → HCID 178429099, compound

HRID 2078337Notes

Reaction equation

HRID 2078337 reaction equation
[OH:1][C:2]1[C:3]([CH3:33])([CH3:32])[C:4]2[C:9]([C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])=[O:13])=[CH:8][CH:7]=[C:6]([CH2:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH:5]=2>C(O)(C(F)(F)F)=O>[OH:1][C:2]1[C:3]([CH3:33])([CH3:32])[C:4]2[C:9]([C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])=[CH:8][CH:7]=[C:6]([CH2:24][CH2:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[CH:5]=2

Participants

3

Reactant 1

HCID 178451292HCID 178451292, compound

Product 1

HCID 178429099HCID 178429099, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Tert-butyl 2-(2-hydroxy-1,1-dimethyl-4-oxo-7-phenethyl-1,4-dihydronaphthalene-3-carboxamido)acetate (130 mg, 289 μmol) was dissolved and stirred in TFA (2 mL) at ambient temperature for 30 minutes. The mixture was then concentrated to give the title compound. MS (ESI) m/z: Calculated; 393.4: Observed; 394.0

Workup

  1. concentrationThe mixture was then concentrated

Sources & evidence

ORD record
ord-8da996727df84acfb8b9fc0a622c2908
Source dataset
uspto-grants-2011_04
Patent number
US07928139B2

Reaction notes

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