Hydrochloric Acid → HCID 86628045, compound

Participants

Reaction Steps

tert-Butyl 7-[3-(4-cyano-2-fluorophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]-nonane-3-carboxylate (9.15 g, 22.5 mmol; see step (ii) above) was taken in 15 mL of dioxane, to which was added 75 mL of diethyl ether saturated with HCl gas. The resulting mixture was stirred for 1 h at RT under a nitrogen atmosphere before solvent was decanted and the precipitated solid washed with dry diethyl ether (4 times) and dried under vacuum. This gave 9 g of the sub-title compound as a pale yellow solid.

Provenance & Evidence