Hydrochloric Acid → HCID 86628045, compound

HRID 2078415Notes

Reaction equation

HRID 2078415 reaction equation
[C:1]([C:3]1[CH:28]=[CH:27][C:6]([O:7][CH2:8][CH2:9][CH2:10][N:11]2[CH2:18][CH:17]3[O:19][CH:13]([CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16]3)[CH2:12]2)=[C:5]([F:29])[CH:4]=1)#[N:2].C(OCC)C.[ClH:35]>O1CCOCC1>[ClH:35].[F:29][C:5]1[CH:4]=[C:3]([CH:28]=[CH:27][C:6]=1[O:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:18][CH:17]2[O:19][CH:13]([CH2:14][NH:15][CH2:16]2)[CH2:12]1)[C:1]#[N:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 86628046HCID 86628046, compound

Product 1

HCID 86628045HCID 86628045, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 7-[3-(4-cyano-2-fluorophenoxy)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]-nonane-3-carboxylate (9.15 g, 22.5 mmol; see step (ii) above) was taken in 15 mL of dioxane, to which was added 75 mL of diethyl ether saturated with HCl gas. The resulting mixture was stirred for 1 h at RT under a nitrogen atmosphere before solvent was decanted and the precipitated solid washed with dry diethyl ether (4 times) and dried under vacuum. This gave 9 g of the sub-title compound as a pale yellow solid.

Workup

  1. customwas decanted
  2. washthe precipitated solid washed with dry diethyl ether (4 times)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-618a6516b76343d9bf6c354a4763e0a6
Source dataset
uspto-grants-2011_04
Patent number
US07928225B2

Reaction notes

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