HCID 67097200, compound → HCID 67097400, compound

HRID 2078635Notes

Reaction equation

HRID 2078635 reaction equation
C([O:4][CH2:5][CH2:6][CH2:7][S:8]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([B:20]([OH:22])[OH:21])=[CH:16][C:15]=1[CH:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1)=[O:13])(=[O:10])=[O:9])(=O)C>Cl.CO>[CH:23]1([C:15]2[CH:16]=[C:17]([B:20]([OH:21])[OH:22])[CH:18]=[CH:19][C:14]=2[C:12]([NH:11][S:8]([CH2:7][CH2:6][CH2:5][OH:4])(=[O:10])=[O:9])=[O:13])[CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

4

Reactant 1

HCID 67097200HCID 67097200, compound

Product 1

HCID 67097400HCID 67097400, compoundYield 107.7%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

[4-[[[[3-(Acetyloxy)propyl]sulfonyl]amino]carbonyl]-3-cyclopentylphenyl]boronic acid (3.28 g) was dissolved in 2.5N hydrogen chloride in methanol (20 ml) and the mixture was stirred at room temperature for 17 hours. The solvent was removed by evaporation to give [3-cyclopentyl-4-[[[(3-hydroxypropyl)sulfonyl]amino]carbonyl]phenyl]boronic acid (3.16 g) as a brown solid.

Workup

  1. customThe solvent was removed by evaporation

Sources & evidence

ORD record
ord-51127e0be9a742a5bd11c8c47be288eb
Source dataset
uspto-grants-2011_04
Patent number
US07928264B2

Reaction notes

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