Hydrochloric Acid → HCID 23171545, compound

HRID 2078637Notes

Reaction equation

HRID 2078637 reaction equation
Br[CH2:2][CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[S:12]([O-])([O-:15])(=[O:14])=[O:13].[Na+].[Na+].Cl>O.C(O)C>[CH2:5]([O:4][CH2:3][CH2:2][S:12]([OH:15])(=[O:14])=[O:13])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 24436Sodium SulfateHCID 73833Benzene, ((2-bromoethoxy)methyl)-

Product 1

HCID 23171545HCID 23171545, compoundYield 75.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of [(2-bromoethoxy)methyl]benzene (6.0 g) and sodium sulfate (3.9 g) in water (12 ml) and ethanol (36 ml) was refluxed overnight. The mixture was acidified with conc. hydrochloric acid under ice-cooling. The mixture was evaporated under reduced pressure. The residue was suspended in dichloromethane/methanol (4/1) and filtered off through Celite pad. The filtrate was evaporated to give 2-(benzyloxy)ethanesulfonic acid (4.5 g).

Workup

  1. temperaturewas refluxed overnight
  2. temperaturecooling
  3. customThe mixture was evaporated under reduced pressure
  4. filtrationfiltered off through Celite pad
  5. customThe filtrate was evaporated

Sources & evidence

ORD record
ord-9cf1a4e8899546049ca054822f929375
Source dataset
uspto-grants-2011_04
Patent number
US07928264B2

Reaction notes

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