Ammonium Hydroxide → 4-Bromo-2-fluorobenzenesulphonamide

HRID 2078640Notes

Reaction equation

HRID 2078640 reaction equation
[OH-].[NH4+:2].[Br:3][C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[C:6]([F:14])[CH:5]=1>ClCCl>[Br:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:2])(=[O:12])=[O:11])=[C:6]([F:14])[CH:5]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 27363104-Bromo-2-fluorobenzene-1-sulfonyl chloride

Product 1

HCID 27789034-Bromo-2-fluorobenzenesulphonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To an ammonium hydroxide (28%, 80 ml) was added a solution of 4-bromo-2-fluorobenzenesulfonyl chloride (10 g) in dichloromethane (80 ml) dropwise for 1 hour at approximately 0° C. The reaction mixture was stirred vigorously for an additional 2 hours at the same temperature. The phases were separated. The aqueous phase was washed with dichloromethane. The combined organic extracts were washed with brine, dried over sodium sulfate and evaporated to give 4-bromo-2-fluorobenzenesulfonamide (8.0 g).

Workup

  1. customThe phases were separated
  2. washThe aqueous phase was washed with dichloromethane
  3. washThe combined organic extracts were washed with brine
  4. dry with materialdried over sodium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-59e6c8bb34d641a68a2c8f342c5acc82
Source dataset
uspto-grants-2011_04
Patent number
US07928264B2

Reaction notes

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