Hydrochloric Acid → HCID 67097716, compound

Participants

Reaction Steps

To a solution of tert-butyl [(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][2-[4′-[[[(3-hydroxypropyl)sulfonyl]amino]-carbonyl]-3′-isopropoxy-4-biphenylyl]ethyl]carbamate (231 mg) in 1,4-dioxane (2.3 ml) was added 4N hydrogen chloride in 1,4-dioxane (2.3 ml) and the mixture was stirred at room temperature for 5 hours. The precipitates were collected by filtration, washed with 1,4-dioxane, and dried under reduced pressure to give 4′-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-N-[(3-hydroxypropyl)sulfonyl]-3-isopropoxy-4-biphenylcarboxamide hydrochloride (158 mg) as a white solid.

Provenance & Evidence