Hydrochloric Acid → HCID 67097716, compound

HRID 2078641Notes

Reaction equation

HRID 2078641 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]([OH:46])[CH2:9][N:10]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([NH:34][S:35]([CH2:38][CH2:39][CH2:40][OH:41])(=[O:37])=[O:36])=[O:33])=[C:28]([O:42][CH:43]([CH3:45])[CH3:44])[CH:27]=3)=[CH:22][CH:21]=2)C(=O)OC(C)(C)C)[CH:5]=[CH:6][CH:7]=1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]([OH:46])[CH2:9][NH:10][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([NH:34][S:35]([CH2:38][CH2:39][CH2:40][OH:41])(=[O:37])=[O:36])=[O:33])=[C:28]([O:42][CH:43]([CH3:44])[CH3:45])[CH:27]=3)=[CH:22][CH:21]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67098037HCID 67098037, compound

Product 1

HCID 67097716HCID 67097716, compoundYield 151%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl [(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][2-[4′-[[[(3-hydroxypropyl)sulfonyl]amino]-carbonyl]-3′-isopropoxy-4-biphenylyl]ethyl]carbamate (231 mg) in 1,4-dioxane (2.3 ml) was added 4N hydrogen chloride in 1,4-dioxane (2.3 ml) and the mixture was stirred at room temperature for 5 hours. The precipitates were collected by filtration, washed with 1,4-dioxane, and dried under reduced pressure to give 4′-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-N-[(3-hydroxypropyl)sulfonyl]-3-isopropoxy-4-biphenylcarboxamide hydrochloride (158 mg) as a white solid.

Workup

  1. filtrationThe precipitates were collected by filtration
  2. washwashed with 1,4-dioxane
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-2940c70da94444b2bd8690b0e78b4bc9
Source dataset
uspto-grants-2011_04
Patent number
US07928264B2

Reaction notes

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