Hydrogen chloride-ethyl acetate → HCID 67097990, compound

Participants

Reaction Steps

To a solution of tert-butyl [(2R)-2-hydroxy-2-phenylethyl][2-[3′-(isopropylthio)-4′-[[[(2-methoxyethyl)sulfonyl]amino]carbonyl]-4-biphenylyl]ethyl]carbamate (3.92 g) in ethyl acetate (20 ml) was added hydrogen chloride ethyl acetate solution (4M, 20 ml) and stirred at room temperature overnight. The resulting solid was collected by filtration and dried to give 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-(isopropylthio)-N-[(2-methoxyethyl)sulfonyl]-4-biphenylcarboxamide hydrochloride (3.15 g).

Provenance & Evidence