Hydrogen chloride-ethyl acetate → HCID 67097990, compound

HRID 2078646Notes

Reaction equation

HRID 2078646 reaction equation
[OH:1][C@H:2]([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[CH2:3][N:4]([CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([NH:28][S:29]([CH2:32][CH2:33][O:34][CH3:35])(=[O:31])=[O:30])=[O:27])=[C:22]([S:36][CH:37]([CH3:39])[CH3:38])[CH:21]=2)=[CH:16][CH:15]=1)C(=O)OC(C)(C)C.C(OC(=O)C)C.[ClH:52]>C(OCC)(=O)C>[ClH:52].[OH:1][C@H:2]([C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)[CH2:3][NH:4][CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([NH:28][S:29]([CH2:32][CH2:33][O:34][CH3:35])(=[O:30])=[O:31])=[O:27])=[C:22]([S:36][CH:37]([CH3:39])[CH3:38])[CH:21]=2)=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67097861HCID 67097861, compound

Product 1

HCID 67097990HCID 67097990, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl [(2R)-2-hydroxy-2-phenylethyl][2-[3′-(isopropylthio)-4′-[[[(2-methoxyethyl)sulfonyl]amino]carbonyl]-4-biphenylyl]ethyl]carbamate (3.92 g) in ethyl acetate (20 ml) was added hydrogen chloride ethyl acetate solution (4M, 20 ml) and stirred at room temperature overnight. The resulting solid was collected by filtration and dried to give 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-(isopropylthio)-N-[(2-methoxyethyl)sulfonyl]-4-biphenylcarboxamide hydrochloride (3.15 g).

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-0856143973ad45689751a7d900448a19
Source dataset
uspto-grants-2011_04
Patent number
US07928264B2

Reaction notes

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