Hydrochloric Acid → HCID 11585471, compound

Participants

Reaction Steps

A mixture of tert-butyl [2-[3′-(isopropylthio)-4′-[[(3-pyridylsulfonyl)amino]carbonyl]-4-biphenylyl]-ethyl][(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]carbamate (411 mg) and hydrogen chloride in methanol (10%, 8.22 ml) was stirred at room temperature overnight. The mixture was evaporated and recrystallized from ethanol to give 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-(isopropylthio)-N-(3-pyridylsulfonyl)-4-biphenylcarboxamide dihydrochloride (242 mg).

Provenance & Evidence