Hydrochloric Acid → HCID 11585471, compound

HRID 2078668Notes

Reaction equation

HRID 2078668 reaction equation
[CH:1]([S:4][C:5]1[CH:6]=[C:7]([C:23]2[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][N:31]([CH2:39][C@@H:40]([C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)[O:41]C3CCCCO3)C(=O)OC(C)(C)C)=[CH:25][CH:24]=2)[CH:8]=[CH:9][C:10]=1[C:11]([NH:13][S:14]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)(=[O:16])=[O:15])=[O:12])([CH3:3])[CH3:2].[ClH:54]>CO>[ClH:54].[ClH:54].[OH:41][C@H:40]([C:48]1[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=1)[CH2:39][NH:31][CH2:30][CH2:29][C:26]1[CH:27]=[CH:28][C:23]([C:7]2[CH:8]=[CH:9][C:10]([C:11]([NH:13][S:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)(=[O:16])=[O:15])=[O:12])=[C:5]([S:4][CH:1]([CH3:2])[CH3:3])[CH:6]=2)=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67098022HCID 67098022, compound

Product 1

HCID 11585471HCID 11585471, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of tert-butyl [2-[3′-(isopropylthio)-4′-[[(3-pyridylsulfonyl)amino]carbonyl]-4-biphenylyl]-ethyl][(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]carbamate (411 mg) and hydrogen chloride in methanol (10%, 8.22 ml) was stirred at room temperature overnight. The mixture was evaporated and recrystallized from ethanol to give 4′-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]-3-(isopropylthio)-N-(3-pyridylsulfonyl)-4-biphenylcarboxamide dihydrochloride (242 mg).

Workup

  1. customThe mixture was evaporated
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-52623a054c7a488d9101d529a2db8e2e
Source dataset
uspto-grants-2011_04
Patent number
US07928264B2

Reaction notes

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