Hydrochloric Acid → HCID 67097169, compound

HRID 2078671Notes

Reaction equation

HRID 2078671 reaction equation
C(OC([N:8]([CH2:41][C@H:42]([O:49][Si](C(C)(C)C)(C)C)[C:43]1[CH:44]=[N:45][CH:46]=[CH:47][CH:48]=1)[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([NH:25][S:26]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])(=[O:28])=[O:27])=[O:24])=[C:19]([O:34][CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[CH:18]=2)=[CH:13][CH:12]=1)=O)(C)(C)C.[ClH:57]>O1CCOCC1>[ClH:57].[ClH:57].[CH:35]1([O:34][C:19]2[CH:18]=[C:17]([C:14]3[CH:13]=[CH:12][C:11]([CH2:10][CH2:9][NH:8][CH2:41][C@H:42]([OH:49])[C:43]4[CH:44]=[N:45][CH:46]=[CH:47][CH:48]=4)=[CH:16][CH:15]=3)[CH:22]=[CH:21][C:20]=2[C:23]([NH:25][S:26]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])(=[O:27])=[O:28])=[O:24])[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67097798HCID 67097798, compound

Product 1

HCID 67097169HCID 67097169, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 3-[[[[4′-[2-[(tert-Butoxycarbonyl)[(2R)-2-[[tert-butyl(dimethyl)silyl]oxy]-2-(3-pyridyl)ethyl]amino]ethyl]-3-(cyclohexyloxy)-4-biphenylyl]carbonyl]amino]sulfonyl]-propionic acid (49.7 mg) was added 4N hydrogen chloride in 1,4-dioxane (1.5 ml). After stirring at room temperature for 12 hours, the mixture was evaporated to give 3-[[[[3-(cyclohexyloxy)-4′-[2-[[(2R)-2-hydroxy-2-(3-pyridyl)ethyl]amino]ethyl]-4-biphenylyl]carbonyl]amino]sulfonyl]propanoic acid dihydrochloride (41.0 mg).

Workup

  1. customthe mixture was evaporated

Sources & evidence

ORD record
ord-c015036fe2394615ae5bb9a0e787520c
Source dataset
uspto-grants-2011_04
Patent number
US07928264B2

Reaction notes

Loading…