Hydrochloric Acid → HCID 67098283, compound

HRID 2078672Notes

Reaction equation

HRID 2078672 reaction equation
[CH:1]1([O:7][C:8]2[CH:9]=[C:10]([C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][N:32]([CH2:40][C@H:41]([OH:48])[C:42]4[CH:43]=[N:44][CH:45]=[CH:46][CH:47]=4)C(=O)OC(C)(C)C)=[CH:26][CH:25]=3)[CH:11]=[CH:12][C:13]=2[C:14]([NH:16][S:17]([CH2:20][CH2:21][CH2:22][OH:23])(=[O:19])=[O:18])=[O:15])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:49]>O1CCOCC1>[ClH:49].[ClH:49].[CH:1]1([O:7][C:8]2[CH:9]=[C:10]([C:24]3[CH:25]=[CH:26][C:27]([CH2:30][CH2:31][NH:32][CH2:40][C@H:41]([OH:48])[C:42]4[CH:43]=[N:44][CH:45]=[CH:46][CH:47]=4)=[CH:28][CH:29]=3)[CH:11]=[CH:12][C:13]=2[C:14]([NH:16][S:17]([CH2:20][CH2:21][CH2:22][OH:23])(=[O:18])=[O:19])=[O:15])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67097248HCID 67097248, compound

Product 1

HCID 67098283HCID 67098283, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl [2-[3′-(cyclohexyloxy)-4′-[[[(3-hydroxypropyl)sulfonyl]amino]carbonyl]-4-biphenylyl]ethyl][(2R)-2-hydroxy-2-(3-pyridyl)ethyl]-carbamate (110 mg) in 1,4-dioxane (1.5 ml) was added hydrogen chloride in 1,4-dioxane (4N, 1.5 ml) at room temperature and the mixture was stirred at the same temperature overnight. The mixture was evaporated under reduced pressure to give 3-(cyclohexyloxy)-N-[(3-hydroxypropyl)sulfonyl]-4′-[2-[[(2R)-2-hydroxy-2-(3-pyridyl)ethyl]amino]ethyl]-4-biphenylcarboxamide dihydrochloride (105 mg) as a white solid.

Workup

  1. customThe mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-045a49c8d022465abcf52fc3cfb11d2f
Source dataset
uspto-grants-2011_04
Patent number
US07928264B2

Reaction notes

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