Sodium Hydroxide → HCID 11699853, compound

HRID 2078674Notes

Reaction equation

HRID 2078674 reaction equation
Cl.Cl.[CH:3]1([O:9][C:10]2[CH:11]=[C:12]([C:26]3[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][NH:34][CH2:35][C@H:36]([OH:43])[C:37]4[CH:38]=[N:39][CH:40]=[CH:41][CH:42]=4)=[CH:28][CH:27]=3)[CH:13]=[CH:14][C:15]=2[C:16]([NH:18][S:19]([CH2:22][CH2:23][CH2:24][OH:25])(=[O:21])=[O:20])=[O:17])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[OH-].[Na+]>O>[CH:3]1([O:9][C:10]2[CH:11]=[C:12]([C:26]3[CH:27]=[CH:28][C:29]([CH2:32][CH2:33][NH:34][CH2:35][C@H:36]([OH:43])[C:37]4[CH:38]=[N:39][CH:40]=[CH:41][CH:42]=4)=[CH:30][CH:31]=3)[CH:13]=[CH:14][C:15]=2[C:16]([NH:18][S:19]([CH2:22][CH2:23][CH2:24][OH:25])(=[O:20])=[O:21])=[O:17])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67098283HCID 67098283, compound

Product 1

HCID 11699853HCID 11699853, compoundYield 93.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 3-(cyclohexyloxy)-N-[(3-hydroxypropyl)sulfonyl]-4′-[2-[[(2R)-2-hydroxy-2-(3-pyridyl)ethyl]amino]ethyl]-4-biphenylcarboxamide dihydrochloride (1.2 g) in water (5 ml) was added 1N sodium hydroxide aqueous solution (3.7 ml). The obtained solid was filtrated and then followed by crystallization from isopropyl alcohol to give 3-(cyclohexyloxy)-N-[(3-hydroxypropyl)sulfonyl]-4′-[2-[[(2R)-2-hydroxy-2-(3-pyridyl)ethyl]amino]ethyl]-4-biphenylcarboxamide (1.0 g).

Workup

  1. filtrationThe obtained solid was filtrated
  2. customfollowed by crystallization from isopropyl alcohol

Sources & evidence

ORD record
ord-5cc2fcbbf5044a9e8cdc35aba71d8d1f
Source dataset
uspto-grants-2011_04
Patent number
US07928264B2

Reaction notes

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