Sodium Hydroxide → HCID 11699853, compound

Participants

Reaction Steps

To a solution of 3-(cyclohexyloxy)-N-[(3-hydroxypropyl)sulfonyl]-4′-[2-[[(2R)-2-hydroxy-2-(3-pyridyl)ethyl]amino]ethyl]-4-biphenylcarboxamide dihydrochloride (1.2 g) in water (5 ml) was added 1N sodium hydroxide aqueous solution (3.7 ml). The obtained solid was filtrated and then followed by crystallization from isopropyl alcohol to give 3-(cyclohexyloxy)-N-[(3-hydroxypropyl)sulfonyl]-4′-[2-[[(2R)-2-hydroxy-2-(3-pyridyl)ethyl]amino]ethyl]-4-biphenylcarboxamide (1.0 g).

Provenance & Evidence