Benzenamine, 2-chloro-N-methyl- → 7-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

HRID 2078789Notes

Reaction equation

HRID 2078789 reaction equation
[Br:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][C:11]3[CH:15]=[C:14]([C:16]([OH:18])=O)[S:13][C:12]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[NH:22][CH3:23]>>[Br:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][C:11]3[CH:15]=[C:14]([C:16]([N:22]([C:21]4[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=4[Cl:19])[CH3:23])=[O:18])[S:13][C:12]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 136736Benzenamine, 2-chloro-N-methyl-HCID 668695327-Bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxylic acid

Product 1

HCID 442421657-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Procedure

Following Example 70 and General Procedure B, 114 was prepared from 7-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxylic acid and 2-chloro-N-methylaniline. MS: (ESI+) 450.0

Sources & evidence

ORD record
ord-8f0b7405237e4558b7101cf88269ef84
Source dataset
uspto-grants-2011_04
Patent number
US07928248B2

Reaction notes

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