Tetrahydropyran-2-methanol → HCID 58010761, compound

HRID 2079406Notes

Reaction equation

HRID 2079406 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][OH:8].[N:9]1([C:14](N2C=CN=C2)=[O:15])[CH:13]=[CH:12][N:11]=[CH:10]1>C(Cl)Cl>[N:9]1([C:14]([O:8][CH2:7][CH:2]2[CH2:3][CH2:4][CH2:5][CH2:6][O:1]2)=[O:15])[CH:13]=[CH:12][N:11]=[CH:10]1

Participants

4

Reactant 2

HCID 7524Tetrahydropyran-2-methanolHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 58010761HCID 58010761, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
50 °C

Procedure

To a mixture of (tetrahydro-2H-pyran-2-yl)methanol (369 mg, 3.17 mmol) and di(1H-imidazol-1-yl)methanone (1.03 g, 6.35 mmol) was added 10.5 mL of CH2Cl2. The reaction was stirred at 50° C. for 3 hours. The reaction mixture was used without further purification. LC/MS: m/z 211.1 (M+H)+ at 0.94 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).

Workup

  1. customThe reaction mixture was used without further purification
  2. waitLC/MS: m/z 211.1 (M+H)+ at 0.94 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA))

Sources & evidence

ORD record
ord-a19b374d516b437bac61878d4ada0a32
Source dataset
uspto-grants-2011_04
Patent number
US07928107B2

Reaction notes

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