反应详情

温度

100 °C

A mixture of 6-chloro-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile is (5.9 g), 4-(2-methoxy-ethoxymethoxy)-3-trifluoromethyl-phenyl-boronic acid (9.92 g), potassium phosphate (11.1 g), tris(dibenzylideneacetone)dipalladium (1.4 g) and tricyclohexylphosphine (1.03 g) in dioxane (190 ml) and water (60 ml) was heated at 100° C. under nitrogen atmosphere for 2 hours. After cooling to room temperature, the mixture was then extracted with ethyl acetate (500 ml×2), the combined organic layers were dried over sodium sulphate and solvent was then removed under reduced pressure. To the residue was then added methanol (20 ml), and the solid product, 6-(4-(2-methoxy-ethoxymethoxy)-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile was collected by filtration (8.95 g).

1. temperatureAfter cooling to room temperature
2. extractionthe mixture was then extracted with ethyl acetate (500 ml×2)
3. dry with materialthe combined organic layers were dried over sodium sulphate and solvent
4. customwas then removed under reduced pressure
5. filtrationadded methanol (20 ml), and the solid product, 6-(4-(2-methoxy-ethoxymethoxy)-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile was collected by filtration (8.95 g)