反应详情

A mixture of 3,4-diamino-6-chloropicolinonitrile (3.2 g), triethylorthoformate (16 ml) and AcOH (5.4 ml) was heated to 150° C. in DCM (16 ml) in a microwave for 15 minutes. Solvent was evaporated, residue was dissolved in EtOAc (250 mL) and washed with water (150 mL). Organic layer was dried over sodium sulphate. Solvent was evaporated under reduced pressure to yield 6-chloro-1H-imidazo[4,5-c]pyridine-4-carbonitrile (2.2 g).

1. customSolvent was evaporated
2. dissolutionresidue was dissolved in EtOAc (250 mL)
3. washwashed with water (150 mL)
4. dry with materialOrganic layer was dried over sodium sulphate
5. customSolvent was evaporated under reduced pressure