HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 6-Chloro-1H-imidazo[4,5-C]pyridine-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 3,4-Diamino-6-chloropyridine-2-carbonitrile | HCID 59218344 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Chloro-1H-imidazo[4,5-C]pyridine-4-carbonitrile | HCID 45120583 | — |
Reaction Steps
A mixture of 3,4-diamino-6-chloropicolinonitrile (3.2 g), triethylorthoformate (16 ml) and AcOH (5.4 ml) was heated to 150° C. in DCM (16 ml) in a microwave for 15 minutes. Solvent was evaporated, residue was dissolved in EtOAc (250 mL) and washed with water (150 mL). Organic layer was dried over sodium sulphate. Solvent was evaporated under reduced pressure to yield 6-chloro-1H-imidazo[4,5-c]pyridine-4-carbonitrile (2.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932251B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-43b04cbf6f794fea943b7891296d06d4 |
| Source note | uspto-grants-2011_04 |