Hydrochloric Acid → HCID 67103507, compound

HRID 2079572Notes

Reaction equation

HRID 2079572 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N:9]2[C:13]3[N:14]=[C:15]([CH3:26])[N:16]=[C:17]([N:18]4[CH2:23][CH2:22][CH:21]([CH2:24][OH:25])[CH2:20][CH2:19]4)[C:12]=3[C:11]([CH3:27])=[CH:10]2)=[C:4]([CH3:28])[CH:3]=1.[ClH:29]>O>[ClH:29].[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N:9]2[C:13]3[N:14]=[C:15]([CH3:26])[N:16]=[C:17]([N:18]4[CH2:23][CH2:22][CH:21]([CH2:24][OH:25])[CH2:20][CH2:19]4)[C:12]=3[C:11]([CH3:27])=[CH:10]2)=[C:4]([CH3:28])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 104785674-Piperidinemethanol, 1-(7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo(2,3-d)pyrimidin-4-yl)-

Product 1

HCID 67103507HCID 67103507, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of {1-[7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperidin-4-yl}methanol (0.71 g) in water (7 mL) was added concentrated HCl aqueous solution (0.15 mL) under ice-cooling. The mixture was stirred at room temperature for 5 minutes, cooled with an ice-bath again, and stirred for 15 minutes in an ice-cooling bath. The precipitate was collected by filtration, washed with water and dried to give the title compound (0.73 g).

Workup

  1. temperaturecooling
  2. temperaturecooled with an ice-bath again
  3. temperaturecooling bath
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-6ab1c1d90f304edd93219114a3541382
Source dataset
uspto-grants-2011_04
Patent number
US07932259B2

Reaction notes

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