Urea → HCID 178486945, compound

HRID 2079614Notes

Reaction equation

HRID 2079614 reaction equation
[NH2:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][C:7]([Br:12])=[CH:6][C:3]=1[CH:4]=O.[NH2:13][C:14](N)=[O:15]>O>[Br:12][C:7]1[CH:6]=[C:3]2[C:2](=[C:9]([O:10][CH3:11])[CH:8]=1)[N:1]=[C:14]([OH:15])[N:13]=[CH:4]2

Participants

4

Reactant 2

HCID 1176UreaHCID 153804452-Amino-5-bromo-3-methoxybenzaldehyde2×

Product 1

HCID 178486945HCID 178486945, compoundYield 111%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
180 °C

Procedure

The mixture of 2-amino-5-bromo-3-methoxybenzaldehyde (43.96 mmol, crude material from step 3) and urea (35 g, 583 mmol) from the previous step was heated to 180° C. under argon for 1 hour. Water (300 mL) was added after cooling to room temperature. The solid was collected by filtration and air dried to give 12.45 g of powder. ES/MS m/z 254/256 (MH+).

Workup

  1. temperatureafter cooling to room temperature
  2. filtrationThe solid was collected by filtration and air
  3. customdried

Sources & evidence

ORD record
ord-94fd9ab0d2f4408d9d017849d6186bd4
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Reaction notes

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