(4-Bromo-2-nitrophenyl)methanol → 4-Bromo-2-nitrobenzaldehyde

HRID 2079638Notes

Reaction equation

HRID 2079638 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1>ClCCl.[O-2].[Mn+4].[O-2]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1

Participants

4

Reactant 1

HCID 15906236(4-Bromo-2-nitrophenyl)methanol

Product 1

HCID 6080994-Bromo-2-nitrobenzaldehydeYield 78%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Manganese (IV) oxide (4 eq) was added to a 0.18M solution of (4-bromo-2-nitrophenyl)methanol in dichloromethane. The suspension was stirred at ambient temperature under Argon for 12 h. The reaction mixture was filtered through celite and filter cake was washed with dichloromethane. The combined filtrate was concentrated to give brown color solid in 78% yield.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. filtrationfilter cake
  3. washwas washed with dichloromethane
  4. concentrationThe combined filtrate was concentrated
  5. customto give brown color solid in 78% yield

Sources & evidence

ORD record
ord-c35dc245435644239b390d654b968345
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Reaction notes

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