HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 7-Bromo-2-chloroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178517417 | HCID 178517417 | — |
| Product | 7-Bromo-2-chloroquinazoline | HCID 45790052 | 65% |
Reaction Steps
A 0.5M suspension of 7-bromoquinazolin-2-ol in phosphorus oxychloride was heated to 110° C. in an oil bath for 1 h. The mixture was cooled to room temperature. Volatiles were removed under reduced pressure. The residue was triturated with ice water. The solid was collected by filtration and air dried to give product in 65% yield. ES/MS m/z 243/245 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932262B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-8f00e4092c3b4dbd924e34bf811c19be |
| Source note | uspto-grants-2011_04 |