反应详情

A 0.5M suspension of 7-bromoquinazolin-2-ol in phosphorus oxychloride was heated to 110° C. in an oil bath for 1 h. The mixture was cooled to room temperature. Volatiles were removed under reduced pressure. The residue was triturated with ice water. The solid was collected by filtration and air dried to give product in 65% yield. ES/MS m/z 243/245 (MH+).

1. customVolatiles were removed under reduced pressure
2. customThe residue was triturated with ice water
3. filtrationThe solid was collected by filtration and air
4. customdried
5. customto give product in 65% yield