Phosphorus oxychloride → 7-Bromo-2-chloroquinazoline

HRID 2079641Notes

Reaction equation

HRID 2079641 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[N:7][C:8](O)=[N:9]2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:15])=O>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[N:7][C:8]([Cl:15])=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178517417HCID 178517417, compound

Product 1

HCID 457900527-Bromo-2-chloroquinazolineYield 65%

Procedure

A 0.5M suspension of 7-bromoquinazolin-2-ol in phosphorus oxychloride was heated to 110° C. in an oil bath for 1 h. The mixture was cooled to room temperature. Volatiles were removed under reduced pressure. The residue was triturated with ice water. The solid was collected by filtration and air dried to give product in 65% yield. ES/MS m/z 243/245 (MH+).

Workup

  1. customVolatiles were removed under reduced pressure
  2. customThe residue was triturated with ice water
  3. filtrationThe solid was collected by filtration and air
  4. customdried
  5. customto give product in 65% yield

Sources & evidence

ORD record
ord-8f00e4092c3b4dbd924e34bf811c19be
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Reaction notes

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