反应详情

A 0.32M suspension of 6-bromo-7-methoxy-N-(4-morpholinophenyl)quinazolin-2-amine (1.0 eq) and sodium thiomethoxide (4.0 eq) in DMF was heated to 80° C. in an oil bath for 12 h. LCMS data indicated the reaction was complete. The mixture was partitioned between ethyl acetate and water. The insoluble solid was filtered off and was rinsed with ether and air dried to give product. ES/MS m/z 401/403 (MH+).

1. customThe mixture was partitioned between ethyl acetate and water
2. filtrationThe insoluble solid was filtered off
3. washwas rinsed with ether and air
4. customdried
5. customto give product