反应详情

To a 1:1 mixture of ethanol and acetic acid was added methyl4-formyl-3-nitrobenzoate (1 eq) and Fe dust (3 eq) was added in portions. The reduction was complete in 1 h. The reaction mixture was filtered and then concentrated and partitioned between ethyl acetate and water. The organic layer was washed with saturated sodium bicarbonate and dried and concentrated to give methyl 4-formyl-3-aminobenzoate in 85% yield. ES/MS m/z 180 (MH+).

1. additionwas added in portions
2. filtrationThe reaction mixture was filtered
3. concentrationconcentrated
4. custompartitioned between ethyl acetate and water
5. washThe organic layer was washed with saturated sodium bicarbonate
6. customdried
7. concentrationconcentrated