Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Methyl 3-amino-4-formylbenzoate | HCID 18412577 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178497297 | HCID 178497297 | — |
Reaction Steps
To methyl 4-formyl-3-aminobenzoate (1 eq) was added urea (5 eq) and the mixture was heated to 145° C. for 16 h. To the crude was added water and the precipitated solid was filtered to give methyl 2-hydroxyquinazolin-7-carboxylate in quantitative yield. ES/MS m/z 205 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07932262B2 |
|---|
| Source dataset | uspto-grants-2011_04 |
|---|
| ORD ID | ord-703e6e721f344d8798f9e8efb9e0a359 |
|---|
| Source note | uspto-grants-2011_04 |
|---|
