Urea → HCID 178497297, compound

HRID 2079651Notes

Reaction equation

HRID 2079651 reaction equation
[CH:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][C:4]=1[NH2:13])=O.[NH2:14][C:15](N)=[O:16]>O>[OH:16][C:15]1[N:14]=[CH:1][C:3]2[C:4](=[CH:5][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:11][CH:12]=2)[N:13]=1

Participants

4

Reactant 2

HCID 1176UreaHCID 18412577Methyl 3-amino-4-formylbenzoate

Product 1

HCID 178497297HCID 178497297, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
145 °C

Procedure

To methyl 4-formyl-3-aminobenzoate (1 eq) was added urea (5 eq) and the mixture was heated to 145° C. for 16 h. To the crude was added water and the precipitated solid was filtered to give methyl 2-hydroxyquinazolin-7-carboxylate in quantitative yield. ES/MS m/z 205 (MH+).

Workup

  1. filtrationthe precipitated solid was filtered

Sources & evidence

ORD record
ord-703e6e721f344d8798f9e8efb9e0a359
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Reaction notes

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