Methanol → HCID 67080801, compound

HRID 2079652Notes

Reaction equation

HRID 2079652 reaction equation
[S:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[N:21]=[CH:20][C:19]3[C:14](=[CH:15][C:16]([C:22]([O-:24])=[O:23])=[CH:17][CH:18]=3)[N:13]=2)=[CH:7][CH:6]=1)(=[O:4])(=[O:3])[NH2:2].[OH-].[Na+].[CH3:27]O>>[CH3:27][C:20]1[C:19]2[C:14](=[CH:15][C:16]([C:22]([OH:24])=[O:23])=[CH:17][CH:18]=2)[N:13]=[C:12]([NH:11][C:8]2[CH:7]=[CH:6][C:5]([S:1](=[O:3])(=[O:4])[NH2:2])=[CH:10][CH:9]=2)[N:21]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 86639319HCID 86639319, compound

Product 1

HCID 67080801HCID 67080801, compound

Conditions

Temperature
80 °C

Procedure

To 2-(4-sulfamoylphenyl amino)quinazolin-7-carboxylate was added 2N sodium hydroxide (4 eq) and methanol and the mixture was heated to 80° C. for 10 min. The saponification went to completion. The reaction mixture was concentrated and 1N HCl was added to precipitate methyl 2-(4-sulfamoylphenylamino)quinazolin-7-carboxylic acid as the HCl salt in quantitative yield. ES/MS m/z 344 (MH+).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. addition1N HCl was added
  3. customto precipitate methyl 2-(4-sulfamoylphenylamino)quinazolin-7-carboxylic acid as the HCl salt in quantitative yield

Sources & evidence

ORD record
ord-717c919bfea44436b9c1e1e2267e0707
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Reaction notes

Loading…