Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 86639319 | HCID 86639319 | — |
| Product | HCID 67080801 | HCID 67080801 | — |
Reaction Steps
To 2-(4-sulfamoylphenyl amino)quinazolin-7-carboxylate was added 2N sodium hydroxide (4 eq) and methanol and the mixture was heated to 80° C. for 10 min. The saponification went to completion. The reaction mixture was concentrated and 1N HCl was added to precipitate methyl 2-(4-sulfamoylphenylamino)quinazolin-7-carboxylic acid as the HCl salt in quantitative yield. ES/MS m/z 344 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07932262B2 |
|---|
| Source dataset | uspto-grants-2011_04 |
|---|
| ORD ID | ord-717c919bfea44436b9c1e1e2267e0707 |
|---|
| Source note | uspto-grants-2011_04 |
|---|
