HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2079656Generated: October 29, 2026
Benzenamine, 4-(4-morpholinyl)- → 5-Chloro-2-(4-morpholinophenylamino) quinazolin-8-ol
https://huagongshe.com/reaction/2079656
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzenamine, 4-(4-morpholinyl)- | HCID 75655 | — |
| Reactant | 2,5-Dichloroquinazolin-8-ol | HCID 59199221 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 5-Chloro-2-(4-morpholinophenylamino) quinazolin-8-ol | HCID 59199300 | — |
Reaction Steps
To a solution of isolated 2,5-dichloroquinazolin-8-ol (1 eq) in isopropanol was added 4-morpholinoaniline (1 eq) and the mixture was heated to 90° C. for 1 h. The SNAR went to completion by LC/MS and on concentration yielded 5-chloro-2-(4-morpholinophenylamino) quinazolin-8-ol in quantitative yield. ES/MS m/z 357 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932262B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-f58a9ff67a9d490c99a9eb019e4ed027 |
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| Source note | uspto-grants-2011_04 |
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