Acetic Acid → HCID 178488670, compound

HRID 2079659Notes

Reaction equation

HRID 2079659 reaction equation
C[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:6]=1[NH2:13])=O.[NH2:14][C:15](N)=[O:16].[C:18](O)(=O)C>O>[CH3:18][C:10]1[CH:9]=[C:8]([O:11][CH3:12])[CH:7]=[C:6]2[C:5]=1[C:3]([CH3:2])=[N:14][C:15]([OH:16])=[N:13]2

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1176UreaHCID 10442276HCID 10442276, compound

Product 1

HCID 178488670HCID 178488670, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

To methyl 1-(4-methoxy-2-aminophenyl)ethanone (1 eq) was added urea (5 eq) and few mls of acetic acid the mixture was heated to 100° C. for 16 h. To the crude was added water and the precipitated solid was filtered to give methyl 7-methoxy-4-methylquinazolin-2-ol in quantitative yield. ES/MS m/z 191 (MH+).

Workup

  1. filtrationthe precipitated solid was filtered

Sources & evidence

ORD record
ord-a9a2c0b2c0f94704be3af348d82d9abc
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Reaction notes

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