HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2079660Generated: October 30, 2026
Phosphorus oxychloride → 2-Chloro-7-methoxy-4-methylquinazoline
https://huagongshe.com/reaction/2079660
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178487561 | HCID 178487561 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Chloro-7-methoxy-4-methylquinazoline | HCID 59199267 | 60% |
Reaction Steps
To 7-methoxy-4-methylquinazolin-2-ol was added POCl3 and the mixture was added heated to 100° C. for 16 h when the reaction went to completion. To the reaction mixture was added ice and water and the precipitated solid was filtered and dried on the high vacuum overnight to give 2-chloro-7-methoxy-4-methylquinazoline in 60% yield. ES/MS m/z 209 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932262B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-dc301b338bb44a8c840eebb07c5a12e1 |
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| Source note | uspto-grants-2011_04 |
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