Phosphorus oxychloride → 2-Chloro-7-methoxy-4-methylquinazoline

HRID 2079660Notes

Reaction equation

HRID 2079660 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:14])=[N:8][C:9](O)=[N:10]2)=[CH:5][CH:4]=1.O=P(Cl)(Cl)[Cl:17]>O>[Cl:17][C:9]1[N:8]=[C:7]([CH3:14])[C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[N:10]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178487561HCID 178487561, compound

Product 1

HCID 591992672-Chloro-7-methoxy-4-methylquinazolineYield 60%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

To 7-methoxy-4-methylquinazolin-2-ol was added POCl3 and the mixture was added heated to 100° C. for 16 h when the reaction went to completion. To the reaction mixture was added ice and water and the precipitated solid was filtered and dried on the high vacuum overnight to give 2-chloro-7-methoxy-4-methylquinazoline in 60% yield. ES/MS m/z 209 (MH+).

Workup

  1. additionthe mixture was added
  2. filtrationthe precipitated solid was filtered
  3. customdried on the high vacuum overnight

Sources & evidence

ORD record
ord-dc301b338bb44a8c840eebb07c5a12e1
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Reaction notes

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