4-(Morpholine-4-carbonyl)aniline → (4-(7-Bromo-5-chloro-8-methoxyquinazolin-2-ylamino)phenyl) (morpholino)methanone

HRID 2079661노트

반응식

HRID 2079661 반응식
[Br:1][C:2]1[C:11]([O:12][CH3:13])=[C:10]2[C:5]([CH:6]=[N:7][C:8](Cl)=[N:9]2)=[C:4]([Cl:15])[CH:3]=1.[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[O:24])=[CH:19][CH:18]=1>C(O)(C)C>[Br:1][C:2]1[C:11]([O:12][CH3:13])=[C:10]2[C:5]([CH:6]=[N:7][C:8]([NH:16][C:17]3[CH:18]=[CH:19][C:20]([C:23]([N:25]4[CH2:26][CH2:27][O:28][CH2:29][CH2:30]4)=[O:24])=[CH:21][CH:22]=3)=[N:9]2)=[C:4]([Cl:15])[CH:3]=1

참가 물질

4

반응물 2

HCID 5778154-(Morpholine-4-carbonyl)anilineHCID 591993057-Bromo-2,5-dichloro-8-methoxyquinazoline

생성물 1

HCID 67102176(4-(7-Bromo-5-chloro-8-methoxyquinazolin-2-ylamino)phenyl) (morpholino)methanone

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
90 °C

실험 절차

To 7-bromo-2,5-dichloro-8-methoxyquinazoline (1 eq) was added (4-aminophenyl) (morpholino)methanone (1 eq) in isopropanol and the mixture was heated to 90° C. for 16 h. The solid formed was filtered to give (4-(7-bromo-5-chloro-8-methoxyquinazolin-2-ylamino)phenyl) (morpholino)methanone and was confirmed by LC/MS. ES/MS m/z 478 (MH+).

후처리

  1. customThe solid formed
  2. filtrationwas filtered

출처 및 근거

ORD 기록
ord-16c0be6e54cb4baf87d33dcaf197801d
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932262B2

반응 노트

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