Phosphorus oxychloride → 2-Chloro-8-methoxy-4-methylquinazoline

HRID 2079663Notes

Reaction equation

HRID 2079663 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10](O)[N:9]=[C:8]2[CH3:14].O=P(Cl)(Cl)[Cl:17]>O>[Cl:17][C:10]1[N:9]=[C:8]([CH3:14])[C:7]2[C:12](=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][CH:6]=2)[N:11]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178488669HCID 178488669, compound

Product 1

HCID 591992952-Chloro-8-methoxy-4-methylquinazoline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

To 8-methoxy-4-methylquinazolin-2-ol was added POCl3 and the mixture was added heated to 100° C. for 16 h when the reaction went to completion. To the reaction mixture was added ice and water and the precipitated solid was filtered and dried on the high vacuum overnight to give 2-chloro-8-methoxy-4-methylquinazoline. ES/MS m/z 209 (MH+).

Workup

  1. additionthe mixture was added
  2. filtrationthe precipitated solid was filtered
  3. customdried on the high vacuum overnight

Sources & evidence

ORD record
ord-cb1a2d3f4f96466fa11a5bfac61107ab
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Reaction notes

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