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HRID2079670

反应详情

EQUATION

反应方程式

HRID 2079670 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc2[nH]c(=O)[nH]c2c1
HCID66765

2H-Benzimidazol-2-one, 5-amino-1,3-dihydro-

C7H7N3O

结构：CCS(=O)(=O)c1ncc2ccc(OC3CCN(C(=O)OC(C)(C)C)CC3)cc2n1
HCID67102269

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC(Oc2ccc3cnc(Nc4ccc5[nH]c(=O)[nH]c5c4)nc3c2)CC1
HCID67102611

未命名化合物

收率 50%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A solution of tert-butyl 4-(2-(ethylsulfonyl) quinazolin-7-yloxy)piperidine-1-carboxylate (1 eq) and 5-amino-1,3-dihydro-benzimidazole-2-one (5 eq) in acetonitrile was heated in sealed tube at 110° C. for 48 h. The product was filtered, washed and dried. A brown solid, yield 50%. ES/MS m/z 477.5 (MH+).

WORKUP

后处理

  1. filtrationThe product was filtered
  2. washwashed
  3. customdried