HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-hydroxybenzimidazole → tert-butyl 4-(2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-ylamino) quinazolin-7-yloxy)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-hydroxybenzimidazole | HCID 66765 | — |
| Reactant | Tert-butyl 4-(2-(ethylsulfonyl) quinazolin-7-yloxy)piperidine-1-carboxylate | HCID 67102269 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | tert-butyl 4-(2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-ylamino) quinazolin-7-yloxy)piperidine-1-carboxylate | HCID 67102611 | 50% |
Reaction Steps
A solution of tert-butyl 4-(2-(ethylsulfonyl) quinazolin-7-yloxy)piperidine-1-carboxylate (1 eq) and 5-amino-1,3-dihydro-benzimidazole-2-one (5 eq) in acetonitrile was heated in sealed tube at 110° C. for 48 h. The product was filtered, washed and dried. A brown solid, yield 50%. ES/MS m/z 477.5 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932262B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-2cdb2005d53944d4bed28df775abd90e |
| Source note | uspto-grants-2011_04 |