HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2079675Generated: October 26, 2026
3-Chloro-4-morpholinoaniline → Tert-butyl 4-(5-bromo-2-(3-chloro-4-morpholinophenylamino) quinazolin-8-yloxy)piperidine-1-carboxylate
https://huagongshe.com/reaction/2079675
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloro-4-morpholinoaniline | HCID 108661 | — |
| Reactant | Tert-butyl 4-(5-bromo-2-chloroquinazolin-8-yloxy)piperidine-1-carboxylate | HCID 86639323 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Tert-butyl 4-(5-bromo-2-(3-chloro-4-morpholinophenylamino) quinazolin-8-yloxy)piperidine-1-carboxylate | HCID 59199220 | — |
Reaction Steps
A mixture of tert-butyl 4-(5-bromo-2-chloroquinazolin-8-yloxy)piperidine-1-carboxylate (1 eq) and N-(4-amino-2-chlorophenyl) morpholine (1 eq) in isopropanol was heated in a sealed tube at 110° C. for overnight. The reaction mixture was concentrated and proceeds for next step. ES/MS m/z 618.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932262B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-c48f8f4b1d484188b67c311bd92e861e |
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| Source note | uspto-grants-2011_04 |
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