HRID2079675

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID108661

Benzenamine, 3-chloro-4-(4-morpholinyl)-

C10H13ClN2O

结构：CC(C)(C)OC(=O)N1CCC(Oc2ccc(Br)c3cnc(Cl)nc23)CC1

HCID86639323

1,1-Dimethylethyl 4-[(5-bromo-2-chloro-8-quinazolinyl)oxy]-1-piperidinecarboxylate

C18H21BrClN3O3

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(Oc2ccc(Br)c3cnc(Nc4ccc(N5CCOCC5)c(Cl)c4)nc23)CC1

HCID59199220

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

CONDITIONS

反应条件

温度: 110 °C

PROCEDURE

实验过程

A mixture of tert-butyl 4-(5-bromo-2-chloroquinazolin-8-yloxy)piperidine-1-carboxylate (1 eq) and N-(4-amino-2-chlorophenyl) morpholine (1 eq) in isopropanol was heated in a sealed tube at 110° C. for overnight. The reaction mixture was concentrated and proceeds for next step. ES/MS m/z 618.0 (MH+).

WORKUP

后处理

concentrationThe reaction mixture was concentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c48f8f4b1d484188b67c311bd92e861e
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07932262B2
来源说明: uspto-grants-2011_04

反应 SMILES

[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH:13]2[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:14]2)=[C:8]2[C:3]=1[CH:4]=[N:5][C:6](Cl)=[N:7]2.[NH2:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH2:35]2)=[C:30]([Cl:40])[CH:29]=1>C(O)(C)C>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH:13]2[CH2:14][CH2:15][N:16]([C:19]([O:21][C:22]([CH3:24])([CH3:23])[CH3:25])=[O:20])[CH2:17][CH2:18]2)=[C:8]2[C:3]=1[CH:4]=[N:5][C:6]([NH:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]3[CH2:35][CH2:36][O:37][CH2:38][CH2:39]3)=[C:30]([Cl:40])[CH:29]=1)=[N:7]2