HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitro-4-trifluoromethylanisole → 2-Methoxy-5-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitro-4-trifluoromethylanisole | HCID 96748 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Methoxy-5-(trifluoromethyl)aniline | HCID 600637 | 99% |
Reaction Steps
A mixture of 4-methoxy-3-nitrobenzotrifluoride and 10% of 10% Pd/C in methanol was stirred under H2 atmosphere overnight at room temperature. The reaction mixture was filtered through celite, concentrated and dried under vacuum to provide product as an off white solid in 99% yield. ES/MS m/z 192.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932262B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-0e11a43a96194bd6b45518dc8d910a74 |
| Source note | uspto-grants-2011_04 |