HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1R,2R)-2-methyl-cyclopropanecarboxylic acid [3-(2-methyl-2H-indazol-5-yl)-4-pyridin-2-yl-isothiazol-5-yl]-amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-bromo-N,N-dimethylpyridin-2-amine | HCID 14006062 | — |
| Reactant | (1R,2R)-2-methyl-cyclopropane carboxylic acid [4-bromo-3-(2-methyl-2H-indazol-5-yl)-isothiazol-5-yl]-amide | HCID 67103132 | — |
| Reactant | (1R,2R)-2-methyl-cyclopropanecarboxylic acid [4-bromo-3-(2-ethyl-2H-indazol-5-yl)-isothiazol-5-yl]-amide | HCID 67103655 | — |
| Product | (1R,2R)-2-methyl-cyclopropanecarboxylic acid [3-(2-methyl-2H-indazol-5-yl)-4-pyridin-2-yl-isothiazol-5-yl]-amide hydrochloride | HCID 67103556 | — |
Reaction Steps
The following compounds are prepared essentially as described in Example 5 using (6-bromo-pyridin-2-yl)-dimethyl-amine and either (1R,2R)-2-methyl-cyclopropanecarboxylic acid [4-bromo-3-(2-ethyl-2H-indazol-5-yl)-isothiazol-5-yl]-amide or (1R,2R)-2-methyl-cyclopropanecarboxylic acid [4-bromo-3-(2-methyl-2H-indazol-5-yl)-isothiazol-5-yl]-amide. Example 7; is prepared as the free base by omitting treatment with hydrogen chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932274B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-17b82e23b7e7447a9ed64ca2b565f35e |
| Source note | uspto-grants-2011_04 |